Ultrasound data is one of a large number of factors that care provides must take into account to estimate the risk of negative outcomes during pregnancy. Credit: University of Utah Health
A new AI-Based Analysis of Almost 10,000 pregnancies have discovered previously unidented combinations of risk factors linked to serial negative pregnancy outstreams, Including Stillbirthes.
The study also found that there may be up to a tenfold differentce in Risk for infants who are currently treated Identally under Clinical Guidelines.
Nathan Blue, MD, The Senior Author on the Study, Says that Ai Modeel The Researchers Generated Helped Identify a “Really Unexpected” Combination of Factors Associateed With Higher Step Toward More Personalized Risk Assessment and Pregnancy Care.
The new results are Published in BMC Pregnancy and Childbirth,
Unexpected Risks
The Researchers Started With An Existing Dataset of 9,558 Pregnancies Nationwide, which included information on social and physical characteristics ranging from pregnant people of Social Offle Ressure, Medical History, and Fetal Weight, as Well as the outcome of Each Pregnancy. By using ai to look for patterns in the data, they identified new combinations of maternal and fetal characteristics that was linked to unhealthy pregnancy Outcomes Such as Stillbirting.

By Analyzing Nearly 10,000 pregnancies with explainable ai, Researchers Identated New Combinations of Risk Factors and Found that there may be up to a tenfold deFOLDERENCE Identically Under Clinical Guidelines. Credit: Sophia Friesen / University of Utah Health
Usually, female fetuses are at Slightly Lower Risk for Complications Than Male Fetuses-A small but well-freelyized effect. But the research team found that if a pregnant person has pre-existing diabetes, female fetuses are at higher risk than males.
This Previous undetected pattern shows that Ai Model Can Help Researchers Learn New Things About Pregnancy Health, Says Blue, An Assistant Professor of Obstetrics and GYNECOLOGY in the S. School of medicine at the university of utah.
“It detected something that count be used to inform risk
The reserchers were essentially interested in developed better risk estimates for fetuses in the bottom 10% for weight, but not the bottom 3%. These babies are small enough to be concerning, but large enough that they are usually perfectly healthy. Figuring out the best course of action in these cases is challenging: Current Clinical Guidelines Advise Intensive Medical Monitoring for all such pregnancy, which can represent a significant emotional and financial burden.
But the results found that with this fetal weight class, the risk of an unhealthy pregnancy outcome outcome varied widely, from no riskar than an average pregnancy to nearly ten times the average. The risk was based on a combination of factors such as fetal sex, presence or absence of pre-existing diabetes, and presence or absence of a fetal anomaly soch as a heart detection.
Blue emphasizes that the study only detected correlations between variables and doesn Bollywood information on whatsatically causes negative outcomes.
The wide range of risk is backed up by physician intelligence, blue says; Experienced doctors are aware that many low-weight fetuses are healthy and will use many additional factors to make individualized judgment calls about risk and treatment. But an AI Risk-Sessesment tool Cold Provide Important Advantages Over Such “Gut Checks,” Helping Doctor Make Recommendations that are informed, reproducible, and Fair.
Why Ai?
For humans or ai models, estimating pregnancy risks involves taking a very large number of variables into account, from Maternal Health to Ultrasound data. Experienced Clinicians can weight all these variables to make individualized care decisions, but even the best doctors probally would be able to getly to quantify exactly how they are arrowed. Human Factors Like Bias, Mood, or Sleep Deprivation Almost Inevitably Creep into the mix and can subtly Skew Judgment calls as away from ideal care.
To help address this problem, The Researchers Used A Type of Model Called “explainable ES Contributed to that Risk Estimation, and How Much . Unlike the More Familiar “Closed Box” ai, which is larger impenetrable even to experts, the explainable model “Shows its work,” Revealing Sources of Bias so they can be added.
Essentially, explainable ai approximates the flexibility of expert clinical judgment while avoid its figfalls. The researchers’ model is also especially well-scheduled to judgment for rare pregnancy Scenarios, accurately estimating outs for people for people with unique combinations of resk factors. This kind of tool could ultimately help personalize care by guiding informed decisions for people who are the situations are one-off-a-kind.
The researchers still need to test and validate their model in new population to make sure it can predict risk in real- WORLD SITUANS. But blue is hopful that an explainable ai-based model could ultimately help personalize Risk Assessment and treatment during pregnancy.
“AI models can essentially estimate a risk that is specific to a given person’s connection,” He says, “and they can do it transparently and reproducibly, what our brothers can y would be transforial across our Field. “
More information:
AI-Based Analysis of Fetal Growth Restriction in a Prospective Obstetric Cohort Quantifies Compound Risks for Perinatal Morbidity and Mortality and Identtifies Previous Arios, BMC Pregnancy and Childbirth (2025). Doi: 10.1186/s12884-024-07095-6
Citation: AI-Based Pregnancy Analysis Discovers Previous Unknown Warning Signs for Stillbirth and Newborn Complications (2025, January 29) Retrievary 2025 from
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