Bacteria ‘Leking Across Strong Lining’ Cold Indicate Risk of Gastric Cancer, Study Finds

Bacteria ‘Leking Across Strong Lining’ Cold Indicate Risk of Gastric Cancer, Study Finds


Illustral model proposing h. Pylori as the ‘Gatekeeper’ for Bacterial Invasion to the Gastric Lamina Propria. Stages 1-5 are (1) Eubacteria and H. Pylori in the Gastric Surface and Gland, Respectively. (2) H. Pylori Secretes HTRA, which cleaves tight Junction Protein e-Cadherin. Stages 3-5 are as described. Credit: biorxiv (2024). Doi: 10.1101/2024.04.22.590522

A pioneering study has revised new insights into the role of gastric bacteria in stomach cancer development Helicobacter,

The research, LED by Dr. Amanda Rossiter-Pearson at the University of Birmingham, Identated a Crucial Interact Between Helicobacter Pylori and non-H. Pylori Bacteria in the Pre-Cancerous Stage of Gastric Cancer.

Gastric cancer is the fourth leading cause of cancer-Related Deaths Worldwide. Infection with Helicobacter Pylori Bacteria, while asymptomatic for most people, have long been identified as the primery show factor for stomach cancer. However, why only 1% of infections Progress to Gastric Cancer is not fully undersrstood.

If detected early, H. Pylori can be eradicated with antibiotics and this reduces the patient’s risk of developing gastric cancer. However, Once pre-concerous changes develop, antibiotic treatment against H. Pylori Backets Ineffective, Underscoring the Urgent need for alternative interventions.

In recent years, studies have suggested that the gastric microbiome may play a role in the development of cancer. However, these studies lacked data as to where the bacteria localize within the stomach.

Using the latest imaging technology to pinpoint the location of bacteria, scientists was ables was able to see that with H. Pylori exclusively colonized gastric glands, non-h. Pylori bacteria leaked through the stomach lining in the pre-concerous condition, Gastric Intestinal Metaplasia. These findings sugges that bacterial leakage Into Deeper Gastric Tissues May REPRESENT A Previous Overlooming Factor in Cancer Progression.

Researchers say the breakthrough may also explain bey only a mineority of h. Pylori infections lead to gastric cancer and even innovative diagnostic and therapeutic approacles.

Corresponding Author of the Paper Dr. Amanda Rossiter-Pearson from the University of Birmingham Said, “We are excited about the potential of this observation to open a new avenue of research in the prevention of stomach cancer. Antibiotic Treatment Cold be administerred to treat these bacteria.

“We must first determine the identity of these bacteria and undress how the presence of these bacteria in the precanseerous condition impacts on the patient’s risk of development stomach cancer.”

Dr. Talisia Quallo, Research Program Manager at Cancer Research UK, SAID, SAID, “Stomach Cancer has Limited Treated Treatment Options and Poor Survival Rates. Better Approaches are need to Find Earlier, and OFFER TREAD TREAD EARLIER, and Offer Treatment When it is more likely to be successful.

“This research is showing us that the most common type of Bacteria Linked to Stomach Cancer, Helicobacter Pylori, May Work AlongSide Other Bacteria to Drive A Precursor Condition to Stomach Cancer.

“Much more research is needed to understand how this interaction works, and whats out be done to stop it, but from this research we can explore new ways to detect who will go on to detect

More information:
Harriet J. Giddings Et Al, The Gastric Microbiota Invade The Lamina Propria in Helicobacobacter Pylori-Casociated Gastritis and Pre-Cancer, Helicobacter (2025).

biorxiv (2024). Doi: 10.1101/2024.04.22.590522

Provided by University of Birmingham


Citation: Bacteria ‘Leaking Across Stomach Lining’ Could Indicate Risk of Gastric Cancer, Study Finds (2025, February 26) Retrieved 26 February 2025 from

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