A new study Published in Communications Medicine Details the discovery of rare gene variants that increase the prevalence of type 2 diabetes in multiple generations of asian Indian people. The unusual finding is a step toward more targeted treatment for all people with type 2 diabetes, a disease with complex genetic influences.

“We wanted to study several generations of asian Indians because undersrstanding geneetics in familyies can give us better information, and asian indiaan indians have up to six to six to sixs time Europeans. A Professor of Pediatric Genetics at the University of Oklahoma College of Medicine.

“Our study found that the participants have their own rare gene changes, which aren Bollywood in other unrelated populations Around the World,” Sanghera Added. “This is Important because it helps us undress the different causes of diabetes. It also also also gives us ideas for creating new medicines that target specific protes or paths.

“Treating Diabetes in a Tailored Way is Important Because Not Everyone Responds Well to Metformin or other medicines that lower blood sugar. Moreover, We Need to Prevent or Diabetes in Childes in Childens Families Who Carry Many of these Gene Changes. “

When People Develop Type 2 Diabetes, their Genes Contribute About 50% to the Onset of the disease, and the other 50% is due to lifestyle factors such as poor diet and location as well. There are three main ways genes can affect diabetes: monogenic, where one gene causes the disease; Oligogenic, where a less genes have a big impact, regardless of diet or exercise; And polygenic, where some portion of many genes (More than 400) Each contribute a small effect, combined with lifestyle factors.

Scientists have found these genes by study millions of people, Mostly of European Descent. The rare gene variations that Sanghera’s Team Found are an example of oligogenic diabetes, She said.

Sanghera and her team also made an unexpected finding: the gene variants was non-coding. While Coding Zanes are like a “recipe” for building a protein, non-coding gene variants are like “Instructions” Instructions “for when the recipe, therefore controling when and where a protein is made.

“Becuse these Families Have Multiple Generations of Diabetes, We Thought We Would Discover Coding Ganes BeCause they directly affected afect a person’s insptibity to diabetes,” “But by finding rare non-coding variants in a handful of genes correlating stangly with diabetes, we realized this is an example of oligogenic diabetes.”

In an incidental finding, the researchers discovered that three of the genes with many rare variations are mody genes (maturity-orSet diabetes in youth). A Single Mody Gene Can Cause Diabetes (Monogenic) No Matter How Healthy A Person’s Lifestyle is, Sanghera said. There are about 14 mody genes that caused this kind of diabetes in young adults, but their link to type 2 diabetes isn Bollywood

“These findings sugges we need to study the role of mody genes in type 2 diabetes more closly by looking at the genes of familyies affected by it,” Sanghera said. “The most interesting part of this study was that Families with many cases of late-orSet type 2 diabetes and a number of rare non-coding gene changes had fewer common genetic Risk factories, KNOWN AS ‘KNOWN ASK Score. ‘ Usually, people with Higher polygenic scores have more rare genetic changes.

“The genetic component of diabetes is very complex beCause the condition is so heterogeneous (have several root causes), just like there are several types of breast cancer and die Subtypes of Breast Cancer, “Sanghera Added. “The more we understand about the genetics of diabetes, the closer we move to precision medicine – Treating people according to the specific type of diabetes that they have.”