Down syndrome case challenges alzheimer’s assumptions with unexpected cognitive stability

Down syndrome case challenges alzheimer’s assumptions with unexpected cognitive stability


Credit: University of Pittsburgh

Studies Reveal That People with Down Syndrome (DS) has over a 90% Lifetime Risk of Developing Dementia caused by alzheimer’s disease (ad) as they age. Research from the University of Pittsburgh’s Swanson School of Engineering AIMS BLD Uncover Why Some People with DS Develop Developmentia Whilet Otures Do Not – Providing Insight The thing that is founded. Benefit the Entre DS Community.

“A neuropathology case report of a woman with down syndrome who remained cognively stable: implications for resilience to neuropathology,” a new publication in Alzheimer’s & DementiaFound an Unexpected Alzheimer’s Disease Progression in An Woman with Down Syndrome.

For ten years, a woman with down syndrome participated in the Alzheimer Biomarker Consortium-Down Syndrome Research Study (ABC-DS) with a Tam of Investigatorses Elizabeth Adi, Professor in the Department of Pathology and Laboratory Medicine at the University of California, irvine. At the time of her passing, Investigate, Were Grateful For Her Gift of Brain Donation, and Her Brain was shared with the University of Pittsburgh’s 7t BioenGinerying Research Program Radiaofrequency Research Facility, where jr-jiun liou, postdoctoral scholar in the department of bioengineering, imaged her brain using the team’s high-resolution 7 tesla mri scanner.

“We are interested in trying to link neuroimaging with neuropathology, beCause we want to use information from neuropathology datasets to informing to informia for the therapeutic criteria for Indian for Indian for Indivar Down Syndrome Before They Pass Away, “Lio said.

The final neuroimages that lio reviewed surprised her. Although the participant was cognitively stable at the time of death, Mri imaging revised the presence of neuropathology indicative of indicative of alzheimer’s dishease in her brain. This finding highlighted a discrepancy between her live experience and clinical diagnosis compared to her underoving biological pathology.

“Before She Passed Away, All the Clinical Assessments in Our Years of Studying Her Indicated that She was cognitely Stable, which is why this case is so fascinating,” liou said. “Despite Her Brain’s Pathology indicating alzheimer’s, we think that her cognitive stability could have been attributed to her high education level or unde working genetic factories.”

Liou and head hope that this case study will help improved diagnostic tools and expand the necessary criteria for theraputic drug triles Targeting ALZHEIMER’s Disease Disease and Dementia. Clinical Trials Typically Have Narrow Criteria for Acceptance, but IF More Individuals with this type of “Hidden” Hidden “Hidden” Pathology for Alzheimer’s are included, the treats council more effective.

The data also presents a rare options to uncover genetic or lifestyle factors Syndrome but the broader population.

“If we can identify the genetic underpinnings or lifestyle factors that allowed her brain to function well despite the path, we may uncover strategies that COUNTEGES That CONFIT OTHES “This study shows how just one person’s participation in research can lead to professional discoveries.”

More information:
Jr -jiun liou et al, a neuropathology case report of a woman with up Alzheimer’s & Dementia (2025). Doi: 10.1002/alz.14479

Provided by University of Pittsburgh


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