Fresh Embryo Transfer May Be a Better Option Than the Use of Frozen Embryos for Women with a Low Chance of Having a Healthy Baby by in Vitro Fortilization (IVF) Published by The bmj Today.

The resarchers say their findings do not support the routine use of the freeze-ball strategy in women with low prognosis of IVF Treatment Success, which can be due to Older Age, Low Quantity or certain underling conditions.

IVF has Revolutionized Infertility Treatment and a Strategy of Freezing All Suitable Embryos Before Transfer (Freeze-Mall Strategy) is now a routine part of treatment Ertility drugs to retrieve fresh eggs.

Most Studies Examining The Freeze-All Strategy Have Focused on Women with a Good Prognosis of IVF Treatment Success, Whoch Showed Similar Cumulative Live Birth Rates Beetween FRESH and FORZEN EMBRANS But it’s unplear white with a low prognosis also benefits from this strategy.

To address this Evidence Gap, Researchers set out to compare live rates after fresh versus frozen embryo transfer in 838 women aged 33-3-34 year with a low Prognosis for IVF TREAT Ertility Centers in China.

Between December 2021 and May 2023, Participants Were Randomly Assigned to Two Groups and Underwent Eiters Frozen or Fresh Embryo Transfer. The live birth rate after the first transfer was then monitored until April 2024.

A Total of 132 (32%) of 419 women in the Frozen Embryo Transfer Group Had a Live Birth Compared With 168 (40%) of 419 in the Fresh Embryo Transfer Group.

The Frozen Embryo group also had a lower rate of pregnancy than the fresh Embryo group – 39% (164 of 419) vs. 47% (197 of 419) –nd a lower cumulative live birth rate after further embryo transfers with one year of randomization – 44% (185 of 419) vs. 51% (215 of 419).

No Differences in Birth Weight, Obstetric Complications, or Illness Risk in Newborns WERE Seen Between the two groups.

The Researchers Acknowledge Some Limitations, Including Differences In the Number and Stage of Embryos Transferred that may partly contribute to the differential to the difference in live birth rate.

However, they say the results add to previous trials of women with good or normal prognosis and capture the spectrum of the benefits and risks of ais-ball strategy compared with the freshe embryo-trick.

They Conclude, “Fresh Embryo Transfer May Be a Better Choice for Women with a Low Prognosis for IVF In Terms of Live Birth Rate Compared with Frozen Embryo TRANSFREO.”

They also say further studies are warranted “to explore the optimal number and stage of embryos for fresh transfer in women with a low prognosis for ivf to have a singleton pregnancy.”

This trial offers valuable insights for women with a poor prognosis in IVF, but concerns remain about potential biases that could have influenced outcomes, write researchers from the Netherlands in a linked editorial.

They point to broader implications, particularly for centers of Igh drawbacks. “

“Properly assessing the effectiveness of these techniques is essential for improving outcomes in this challenging patient population,” They conclude.