Hars exhibit enhancer function in Excitator Neurons. Credit: Nature (2025). Doi: 10.1038/s41586-025-08622-x
How did humans Evolve Brains Capable of Complex Language, Civilization, and More? The answer could lie in exceptional dna. Scientists at UC San Francisco Have Found That Parts of Our Chromosomes Have Evolved at Breakneck Speeds to Give Us An Ede in Ede in Brain Development Compared to Aps. But it might also put us at risk for uniquely human brain disorders.
The study appears in Nature,
The research focused on parts of chromosomes Known as Human Accelerated Regents (Hars), which have evolved most rapidly sincely since heart humans split from chimpanzees on the evolution Than the expected rate of evolution in mammals.
The scientists, LED by Yin Shen, Ph.D., Professor in the UCSF Weill Institute for Neurosciences and the UCSF Institute for Human Gnetics, Study the Effects in Artificial Neurons DERIVED FOMANS Chimpanzee Cell Lines.
The Human and Chimpanzee genomes are 99% Similar. Hars make up a big portion of the 1% difference, which can lead to dramatically different outsomes in human and chimp neurons in petri dishes. The Human Neurons Grew Multiple Neurites, Wiry Projections that help the NERVE CELLS Send and Receive Signals. But the chimp neurons only grew single neurites. When Human Hars was Engineered INTO Artificial Chimp Neurons, The Chimp Neurons Grew Many More of these wires.
“More neurites during development could mean more complexity in our neural networks,” Shen said. “These networks facilitate the transmission of signs in the nervous system and support our higher cornitive functions. Like Autism. “
More information:
Xiekui cui et al, comparative characterization of human accepted regions in neurons, Nature (2025). Doi: 10.1038/s41586-025-08622-x
Citation: Human Chromosomes Evolved at Hypersped to Give US Better Brains, but there’s a catch (2025, February 26) retrieved 27 February 2025 from
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