Monash University Researchers have Reveled How the Gut – Regate We Eat – Regulates High Blood Pressure, Opening the Door to More Specialized Potential New Drugs.

The Project Involved Multiple Researchers from Australia, China and Singapore, And was LED by the Hypertation Research Laboratory at Monash University’s Schole of BioLogist Ques.

The findings are highly significant for the estimated one in three australians who have hypertension, which is a leading cause of stroke, heart disease, heart disease and Kidney Disease.

“We had evidence that dietary fiber, via the production of gut microbial substances called short-key fatty acids, Reduces blood pressure,” Said Professor Marques. “But we didn’t understand how this gut-to-host communication took place.”

The key is in two protein receptors in Intestinal Cells which can be switched on by short-chan fatty acids. These receptors are called GPR41 and GPR43.

“They are called we call ‘G-Protein Coupled Receptors,’ Part of the Larget Group of Recepy on Cell Membranes that activate signaling from the surface to the insertion of cells,” PROFESSOR MARCOSS SAIDE.

“They are highly presented in immune cells and cells of the lining of the intestinal wall. Once they are active, they are known to trigger anflammatory mechanisms.

“What is exciting about them is that the molecules that bind to and activate them are produced by the gut when we get fiber in our diet.”

Dietary Fiber Works by Being Fermened In the Gut By Microbes, which produce short-chan fatty acids. Dietary Fiber Comes from legumes, fruit, vegetables, whole grains, nuts, resistant stars such as oats and potatoes, and seeds. A Major Issue, The Researchers Said, is that most Australians do not eat enough fiber.

The team’s findings are now Published in Circulation Research With a strong focus on gut permeability, or how much it leaks, based on pre-callial lab work.

“Our Study Shows that Lack of Activation of the receptors, copying a situation when we do don’t have enough fiber in our diet, leads to increase gut permeability, oxy Ad Author Dr. Rikeish r muralitharan, a research fellow in the school of biological sciences.

“This Activates Inflammation in Key Organs Such as the Kidney, which regulate blood pressure, and which leads to hypertension. s hypertension may start in the gut, and we demonstrate that GPR41 and 43 are –t Least Partialy-Responsible for the Blood Pressure-Lowering and Cardio-Protective Effects of a High Fiber Diet. “

The Researchers also show through genetic data from Around 300,000 people that some genetic variants mean lower rates of hypertension.

Professor Marques’s Lab is Now Running a Human Clinical Trial to Better Understand Gut Permeability in Hypertension, and is Starting in Vitro Tests of Potential New Drugs to Bind to the resptors.

“We have partnered with computational drug discovery and g -Protein coupled receptor Specialists to Design and Test New Drugs to Activate these receptors, OPNING OPPORTUNITEES FOR NEWS Pressure via the gut, “She said.