Patients with anorexia have elevated opioid neurotransmitter activity in the brain, study shows

Patients with anorexia have elevated opioid neurotransmitter activity in the brain, study shows


Number of opioid receptors in the brain (top row) and sugar intake (bottom row) in patients with anorexia nervosa. Credit: Turku Pet Center

A Study Conducted at Turku Pet Center in Finland Showed that changes in the functioning of opioid neurotransmitters in the brain may underlie anorexia. The results were Published on 12 January 2025 in the journey Molecular psychiatry,

Anorexia nervosa is a serial psychiatric disorder characterized by restricted eating, Fear of Gaining Weight, and Body Image Disturbances, which may lead to Severe Malnutrition, DePRESSION, DAPRESSION, who. New Study from Turku Pet Center Shows how changes in neurotransmitter function in the brain may underlie anorexia.

“Opioid neurotransmission regulates appetiite and pleasure in the brain. Shown that in Obese Patients The activity of the tone of this system is lowered. is likely that Actions of these molecules regulate bot the loss and increase in appetiite, “Says Professor Pirjo Nuutila from the University of Turku, Finland.

In addition, the resultarches measured the brain’s glucose uptake. The brain accounts for about 20% of the body’s total energy consumption, so the results we weed in how a reduction in the energy in the energy intake affects the Brain’s Energy Balance in anorexia.

“The Brains of Patients with Anorexia Nervosa Used A Similar Amount of Glucose as the Brains of the Healthy Control Subjects. ALTHAET BEINGT BURDENS PYDENS PHYSISILOGY In Maan Itself and maintain its ability to function for as long as possible, “Says Professor Lauri Nummenmaa from Turku Pet Center and Continues:

“The Brain Regulates Appetite and Changes in Brain Function Are Associated With BOTH OBESITY and Low Body Weight. May explain the emotional symptoms and mood changes associated With anorexia nervosa. “

The Study was carried out in collaboration with the turku university hospital and pusan national university in south korea. The brains of patients with anorexia nervosa and the healthy control subjects were imaged Using Positron Emission Tomography at Turku Pet Center.

More information:
Kyoungjune pak et al, anorexia nervosa is associated with Higher Brain Mu-OPIOid Receptor Availability, Molecular psychiatry (2025). Doi: 10.1038/s41380-025-02888-3

Provided by University of Turku


Citation: Patients with anorexia have elevated opioid neurotransmitter activity in the brain, study shows (2025, January 27) retrieved 28 January 2025 from

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