Pilot Study Suggessts Senolytic Medications May Boost Cognition in Alzheimer’s Risk Group

Pilot Study Suggessts Senolytic Medications May Boost Cognition in Alzheimer’s Risk Group


Credit: Unsplash/CC0 Public Domain

A New Pilot Study Known as Stamina (Senolytics to Alleviate Mobility issues and neurological impairments in aging), that focused on the effects of Senolytic medications, dasatylice and quercetin (dq) Which Remove Old (SENESCENT) cells from the body, sugges that intermittent treatment may hold promise for improving cognitive function in older adults at Risk of Alzheimeer’s Disease.

Cellular SENESINCE is a Fundamental Process Associated With Aging. Recent evidence sugges that accumulation of senescent cells, which can release a variety of toxic, inflammatory by-products, is one of the drivers of deficits in both cognition and moobility. Senolytic Drugs Like Dq Target and Help Eliminate Senescent Cells, Potentially Slowing Aging and Reducing the risk of age-Related diseases.

Published in the ebiomedicine Journal as “a pilot study of senlytics to improve cognition and mobileity in older adults at risk for alzheimer’s Disease,” The Research Explord the Effects of DQ On Cognition inDevidals With mild cognitive impairment (Mci) and slow gait, which are conditions linked to increase risk of Alzheimer’s Disease.

The results showed an improvement in cognitive scores, particularly among participants with the lowest baseline cognitive function and a reduction in a key inflammatory chemical in the bladed help with the help associal in the blades Cellular aging.

Over 12 weeks, 12 participants took a combination of dasatinib (100mg) and quercetin (1250mg) for two two days every two weeks. Researchers observed a statistically Significant Increase of 2.0 points in the Montreal Cognitive Assessment (Moca) Scores in Participants with the Lowest Baseline Scores, Hinting AT Cognitive benefits. Additional, Reductions in the inflammatory chemical called tumor necrosis factor alpha (TNF-Ī±) correlated with cognitive improvements, suggesting that Senolytics MIGHT ENHANTIVE FUNCTION Fun Reducing inflammation.

“Our findings sugges that Senolytic treatment with dasatinib and quercetin is well-tolerated in older adults at risk for alzheimer’s disease and may improve cognition by targeting the harmful effects of Cellular SENESCENCE, “Said Courtney L. Millar, Ph.D., Assistant Scientist II at the Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniralFe and the Study”s Lead Author.

“These results are promising, but this is a very small pilot study and we do not know if these findings occurred just by chances. Explore the Therapeutic Potential of Senolytics. “

More information:
Courtney l. Millar et al, A Pilot Study of Senolytics to Improve Cognition and Mobility in Older Adults at Risk for Alzheimer’s Disease, ebiomedicine (2025). Doi: 10.1016/j.biom.2025.105612

Provided by Hebrew Seniorlife Hinda and Arthur Marcus Institute for Aging Research

Citation: Pilot Study Suggessts Senolytic Medications May Boost Cognition in Alzheimer’s Risk Group (2025, February 26) retrieved 26 February 2025 from

This document is Subject to copyright. Apart from any Fair Dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

(Tagstotranslate) Medicine Research News (T) Medicine Research (T) Health Research News (T) Health Research (T) Health Science (T) Medicine Science

Leave a Comment

Your email address will not be published. Required fields are marked *