The symptoms of schizophrenia vary great from person to person. A new study appearing in the American Journal of Psychiatry Shows how these differentises manifest themselves in the structure of the brain.

Schizophrenia is a complex mental health condition that affects perception, thought and emotion. This complexity is reflected in the Individual Manifestations of the Disease: For some patients, perceptible disturbances are the main problem, with for others, cognitive importants.

“In this sense, there is not one schizophrenia, but many, ed with different neurobiological profiles,” Says wolfgang omlor, first author of the study and Senior Physician At that Invertersity Hospiti Hospital of Psychiatry zurich.

To do justice to each of these types of schizophrenia, a precision medicine approach have to be adopted – for example, with therapies that preachient match the respective neurobiobiobiobiobiBiobiobiBiLogical Profile.

“This requires approaches that look for both individual differenties and similarities at the neurobiological level,” explains omlor.

Comprehensive International Study of Patients’ Brain Structures

In an international multicenter study, wolfgang omlor and the research team at the university of zurich examined the variable of brain structure in structure in patients with schizophrenia: who schoch degree of individuality and which a high degree of similar?

The researchers examined several characteristics, including the thickness and surface area of ​​the cerebral cortex, as well as the folding pattern and Volume of Deeper Brain regions.

The data was taken from the enigma collaboration, an International Research Project that Combined Imaging Data from more than 6,000 people in 22 counts. By Comparing the Brain Structures of Several Thousand Patients with Schizophrenia and Healthy Individuals, The Variable of Brain Structure Cold be Stodied with a high degree of Relibility.

Less flexible brain development in early childhood revised

While Variable Brain Structures in Schizophrenia May Reflect Differences in Symptoms Between Patients, The Uniformity of Brain Folding in the Mid-FRONTAL BRANTAL BRANTAL BRANTAL BRAMON to People with Schizophrenia. Because brain folding is largerly complete in every childhood, brain development during this period appears to be less flexible in schizophrenia pataients, particularly in isponsible for Linking Thinking and feeling processes.

“These findings broaden our undersrstanding of the neurobiological bases of schizophrenia,” Says philipp home, Professor at the University of Zurich and Corresponding Author of the Study.

“While Uniform Brain Folding May Indicate Possible Mechanisms of Disease Development, Regions with High Variable in Brain Structure May Be Relevant for the Development of Individualized Treatment strategies. “