Tenecteplase has similar safety to tissue plasminogen activator for acute ischemic stroke


For patients with acute ischemic stroke (AIS), tenecteplase (TNK) has improved functional outcome and reduced disability and similar safety to alteplase (tissue plasminogen activator (TPA)), according to a study. published online Oct. 16 inches Neurology,

Lina Palaiodimou, MD, Ph.D., from the National and Kapodistrian University of Athens in Greece, and colleagues conducted a systematic review and meta-analysis of all available randomized controlled trials (RCTs) that examined the efficacy and safety of TNK 0.25 mg. /kg versus TPA for treatment of AIS within 4.5 hours of onset. Data were included for 11 RCTs, with 3,788 patients treated with TNK and 3,757 patients treated with TPA.

The researchers found that compared with TPA, TNK was associated with a higher likelihood of excellent functional outcome (risk ratio, 1.05) and reduced disability at three months (common odds ratio, 1.10), while the groups had similar improved functional outcome. Similar rates of symptomatic intracranial hemorrhage and three-month mortality were observed in the groups. Statistical significance in achieving an excellent functional outcome at three months was retained for the original TNK when stratified for TNK regimen (original versus biocopy; risk ratio, 1.05).

“It demonstrates that TNK is associated with better clinical outcomes, showing superiority over TPA in achieving excellent functional outcome and reduced disability at three months. These findings support transitioning to TNK in clinical practice,” the authors write.

More information:
Lina Palaiodimou et al, Tenecteplase vs Alteplase in Acute Ischemic Stroke Within 4.5 Hours, Neurology (2024). DOI: 10.1212/WNL.0000000000209903

Anna Ranta, The Time Has Come. The Time Is Now. IV Alteplase, Will You Please Go Now?, Neurology (2024). DOI: 10.1212/WNL.0000000000209961

© 2024 HealthDayAll rights reserved.

Citation: Tenecteplase has similar safety to tissue plasminogen activator for acute ischemic stroke (2024, October 17) retrieved 18 October 2024 from

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Leave a Comment

Your email address will not be published. Required fields are marked *