A new approach to Drug Design Can Deliver Medicine Directly to the Gut in Mice at Significantly Lower Doses Than Current Inflammatory Bowel Disease Treatments. The proof-of-concept study, published in ScienceIntroduces a mechanism called “glycocaging” that releases medicine exclusively to the lower gut at doses up to 10 times lower than current therapies.

“With this technique, we have the ability to deliver not just just steroids, but a range of drugs including anti-microbial compounds directly to the gut, potentially helplane with help Disease, gut infections and more, “said co-senior author Dr. Harry Brumor, A Professor in the UBC Department of Chemistry and Michael Smith Laboratories (MSL).

An Estimated 322,600 Canadians Have Inflammatory Bowel Disease (IBD) as of 2023 and canada has one of the highest incidence rates in the world, according to Crohn’s and Colitis Canada,

“It’s a growing problem, and there’s no knowledge cure. It can be complete debilitating and it Hits people in the Prime of their life, their life, between 19 and age age,” Said co-Senir Authear Authear Dr. Laura Sly, Professor in the UBC Department of Pediatrics.

Targeted Drug Delivery

One of the treatments for ibd is anti-inflammatory steroids, often taken orless or intravenously. These have serial side effects include osteoporosis, high blood pressure, diabetes and negative menal health outcomes. They are used to treat flares for children, adults, and the roughly 30% of adults for who treatment with other medication doesn’T work.

Much of the medicine is Absorbed in the stomach and upper Intestine Before Reaching the inflamed gut area, so doctors administer the potent drugs in high doses in high doses to eFFECHES AREASHES AREASHES ARASTEDES ARASTEDES AREAS

Glycocaging is a chemical process inspired by the UBC Researchers’ Realization that Certain Molecules found in fruit and vegetable fiber can only be digested by Bacteria that residy in our gut.

The team bonded the molecule to a steroid, creating a “treasure chest” for which the “key” is a specific gut bacteria. They are used a steroid not usual for IBD treatment to demonstrate glycocaging’s potential to repurpaose potent drugs.

Significantly Lower Doses of Potent Drugs

Using this mechanism, the researchers treated two types of mice that had ibd for up to nine weeks. Their glycocaged doses were three to 10 times lower than non-increased doses but had the same anti-inflammatory effects. The Drug Turned Up in Lower Levels in the rest of the body than the non-trade version. In one group, inflammation in other area of ​​the body was not reduced, meaning the drug indeed affected only the gut.

“We showed that this technique can be used Effects, “said Dr. Changqqing Wang, Research Associate in UBC Department of Chemistry and MSL.

Human potential

To test the potential for treatment in humans, the research team checked to

They looked for bacterial activity in fecal samples from 33 people, with and without ibd, and at a global database for genetic markers.

“We found that all people in the fecal sample study had the ability to activate the drugs, inclusive people with ibd with whether they are in rest or have active information,” Said Maggie (You Jen) A doctoral student in UBC’s Experimental Medicine Program and BC Children’s Hospital Research Institute.

“And, the majority of people had gentic markers indicating the ability to use the glycocage system.”

The research team has patented the technology and aims to conduct more advanced animal trials and human clinical trials.