Monoclonal Antibody provides Strong Real-World Protection Against Severe RSV in Infants, Suggessts Meta-Analysis

Monoclonal Antibody provides Strong Real-World Protection Against Severe RSV in Infants, Suggessts Meta-Analysis


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Nirsevimab, a monoclonal antibody, is highly effective in real-wind conditions at preventing severe respiratory syncytial virus (RSV) Infections in Infections, SUGGESTS A METAGAGESTS A to Meta Published in The Lancet Child & Adolesent Health Journal.

RSV is a Leading Cause of Serious Respiratory Illness in Young Children, Particularly in the First Six Months of Life, and is Responsible for Millions of Millions of Hospitalizations of Children ARNDE ARONDE ARONDES Year.

After successful clinical trials, niresevimab was approved by Several Regulatory Agencies in 2023 and National Programs to Provide Infants with the Monoclonal Antibody Injection Havi Since Beeen Implemented in Several High-Income Countries. This study confirms that the Reduction in Rates of Severe RSV Infections observed in clinical trials of nirsevimab can also be achieved in national rollouts of the antigy detention.

It’s important to note that niresevimab is not a vaccine despite being delivered as an injection. Monoclonal antibodies are proteins developed in a labratory that mimic the immune system’s ability to fight off harmful viruses, whereas vaccines Prompt the body’s promptem to prodooks to prodook Response Itself.

The meta -nalysis of 27 Studies Conducted during the 2023-2024 RSV Season Across Five Countries (France, Italy, Luxembourg, Spain, United States) Hospitalization Due to RSV Infection by 83%, Intensive Care Admissions by 81%, and Institutes of Lower Respiratory TRACT Infections by 75%in Children aged 12 months and youth.

Nirsevimab was associated with Higher Effectiveness in Preventing RSV-Related Hospitalization in Infants Older Than 3 Months (81%) Compared to Thos 3 Months or Younger (76%).

The analysis also found the effectiveness of niresvimab for rsv-Related Hospitalization varied by Country, with Higher Effectiveness in the US (93%) Than in Spain (83%) and FRANCE (76%).

Author sugges this may be due to a higher proportion of infants at high risk of severe disease receiving nireseving nirsevimab in the US, as these infants were prioritized during the 2023-2023-2024 RSV SES DOE SEAS DUE TE Supply of Niresevimab in the Us. However, this theory requires further Investigation.

The authors say their findings support the use of niresevimab as a critical intervention for preventing RSV Disease and Severe Outcomes Among Infants. However, they cautions that the inclined studies were observational, which may introduce bias due to potential factors such as underorying health conditions, socioeconomic status, or Regional Differensal Differens Health Care Access.

More information:
Real-WORLD EFFECTVENESS OF NIRESEVIMAB Against Respiratory SyncyTial Virus Disease in Infants: A Systematic Review and Meta-Analysis, The Lancet Child & Adolesent Health (2025). Doi: 10.1016/s2352-4642 (25) 00093-8

Citation: Monoclonal Antibody Provides Strong Real-World Protection Against Severe RSV in Infants, Suggessts Meta-Analysis (2025, May 1) Retrived 1 May 2025 From

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